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The Role of Human Aldo-Keto Reductases (AKRs) in the Metabolic Activation and Detoxication of Polycyclic Aromatic Hydrocarbons: Interconversion of PAH-catechols and PAH o-Quinones

机译：人类aldo-Keto还原酶（aKRs）在多环芳烃代谢活化和解毒中的作用：paH-儿茶酚和paH邻醌的相互转化

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Li eZhang; Yi eJin; Meng eHuang; Trevor M. Penning;
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1. The Ubiquitous Aldehyde Reductase (AKR1A1) Oxidizes Proximate Carcinogen trans-Dihydrodiols to o-Quinones: Potential Role in Polycyclic Aromatic Hydrocarbon Activation [J] . Nisha T. Palackal, Michael E. Burczynski, Ronald G. Harvey, Biochemistry . 2001,第36期

机译：普遍存在的醛还原酶（AKR1A1）将近致癌物反式二氢二醇氧化为邻喹啉类化合物：在多环芳烃活化中的潜在作用
2. Detoxication of Structurally Diverse Polycyclic Aromatic Hydrocarbon (PAH) o-Quinones by Human Recombinant Catechol-O-methyltransferase (COMT) via O-Methylation of PAH Catechols [J] . Li Zhang, Yi Jin, Mo Chen, The Journal of biological chemistry . 2011,第29期

机译：通过对PAH儿茶酚的O-甲基化的人重组儿茶酚-O-甲基转移酶（COMT）解毒通过o-甲基化的结构各种多环芳烃（PAH）O-醌
3. Polycyclic aromatic hydrocarbon (PAH) o-quinones produced by the aldo-keto-reductases (AKRs) generate abasic sites, oxidized pyrimidines, and 8-oxo-dGuo via reactive oxygen species. [J] . Park JH, Troxel AB, Harvey RG, Chemical research in toxicology . 2006,第5期

机译：醛基酮还原酶（AKR）产生的多环芳烃（PAH）邻醌通过反应性氧生成无碱基位点，氧化的嘧啶和8-氧代-dGuo。
4. Polycyclic aromatic hydrocarbons (PAHs) have much received attention as one of thefundamental components of organic devices.1 Although PAHs are usually composed ofhexagons (benzenoid systems),embedding odd-membered rings such as pentagons orheptagons (non-benzenoid systems) into the molecular core is a promising methodology tomodify their electronic properties,such as aromaticity,redox ability and/or spin state [C] . Koki Horii, Akihito Konishi, MakotoYasuda 日本化学会春季年会 . 2020

机译：多环芳烃（PAHS）作为有机器件的金融组件之一，多环芳烃（PAHS）有很多人受到关注.1虽然PAHS通常由过爆（苯甲酸系统）组成，但嵌入奇数元环，例如Pentagons Orheptagons（非苯骨系统）进入分子核心是一个有希望的方法，可以清理它们的电子性质，例如芳香性，氧化还原能力和/或旋转状态
5. Role of aldo-keto reductase enzymes in polycyclic aromatic hydrocarbon activation. [D] . Shultz Terkhorn, Carol Ann. 2009

机译：醛酮还原酶在多环芳烃活化中的作用。
6. The Role of Human Aldo-Keto Reductases in the Metabolic Activation and Detoxication of Polycyclic Aromatic Hydrocarbons: Interconversion of PAH Catechols and PAH o-Quinones [O] . Li Zhang, Yi Jin, Meng Huang, 2012

机译：人醛基酮还原酶在多环芳烃代谢活化和脱毒中的作用：多环芳烃邻苯二酚和多环芳烃邻喹啉的相互转化
7. The Role of Human Aldo-Keto Reductases in the Metabolic Activation and Detoxication of Polycyclic Aromatic Hydrocarbons: Interconversion of PAH Catechols and PAH o-Quinones [O] . Li Zhang, Yi Jin, Meng Huang, 2012

机译：人类aldo-Keto还原酶在多环芳烃代谢活化和解毒中的作用：paH儿茶酚和paH邻醌的相互转化
8. Metabolic Activation Pathways of Cyclopenta-Fused PAH (Polycyclic Aromatic Hydrocarbons) and Their Relationship to Genetic and Carcinogenic Activity [R] . Nesnow, S. , Gold, A. , Mohapatra, N. , 1985

机译：环戊二烯基多环芳烃（多环芳烃）的代谢活化途径及其与遗传和致癌活性的关系

The Role of Human Aldo-Keto Reductases (AKRs) in the Metabolic Activation and Detoxication of Polycyclic Aromatic Hydrocarbons: Interconversion of PAH-catechols and PAH o-Quinones

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